Comparison of CA125, HE4, and ROMA index for ovarian cancer diagnosis. June 2018; Current Problems in Cancer 43(2) DOI: 10.1016/j.currproblcancer.2018.06.001

agnosed with endometriosis and analyzed their serum markers CA125, HE4, and Risk of. Ovarian Malignancy Algorithm (ROMA) index. We also analyzed all

The risk of ovarian malignancy algorithm (ROMA) score, which combines CA125, HE4, and menopausal status, may improve diagnostic performance. The Roche Elecsys ® HE4 assay is a tumor marker test for use with blood samples to support monitoring and surveillance of ovarian cancer patients and together with Elecsys ® CA 125 II for risk assessment of patients with pelvic mass with the ROMA™ algorithm. CA 125, HE4, and ROMA exhibiting maximum Youden index were determined, respectively, as the optimal cutoffs, and sensitivity and specificity were evaluated by applying those cutoffs. It was concluded that the combined test including three tumor markers, CEA, CA125, and ROMA (which it is a function of CA125 and HE4 for pre- and post-menopausal) can be considered as a suitable biomarker panel related to early detection of ovarian cancer.

Onkomarkery CA124, HE4 a ROMA index pri karcinóme ovária Anna Stecová, Medirex, a.s. Bratislava . Anatómia ovárií - CA125 - HE4 - (ROMA) Onkomarkery L'algorithme ROMA évalue un risque de malignité, en associant les mesures sériques d'HE4, CA125 et le statut ménopausal. Il permet de classer les patientes selon leur niveau de risque de malignité, faible ou élevé, en tenant compte de leur statut ménopausal. Youden index was calculated to choose the optimal threshold. 24 According to the different menopausal status, the threshold which was recommended by the company and the threshold which was calculated from the Youden index of HE4, CA125, and ROMA values were determined for the all, premenopausal, and postmenopausal groups.

In the ovarian cancer group, the areas under ROC curves of ROMA, HE4 and CA-125 were 0.994, 0.990 and 0.941, respectively. The specificity and positive predictive value of HE4 in the premenopausal ovarian cancer group reached 98.36 and 95%, respectively.

Il Laboratorio Analisi Clanis esegue il dosaggio del CA 125 e dell'He4 per il calcolo del rischio di carcinoma ovarico Roma INDEX.

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The results based on the AUC markers of CA125, HE4, RMI, and ROMA of Malignancy Index (RMI), and Risk of Ovarian Malignancy Algorithm (ROMA) as

It is designed to help illustrate how CA125 and HE4 values are combined to estimate risk in both pre- and postmenopausal women.

Results: HE4 had significantly higher concentrations in ovarian cancer than benign gynecologic disorders (p < 0.005). Tumor marker sensitivity in ovarian cancer was 78% for HE4, 63% for CA125, and 88% for ROMA index at 95% specificity. HE4 and CA125 serum levels in each patient were detected and the ROMA index was analyzed. ROC curve analysis was conducted to compare the performances of serum CA125, serum HE4, and ROMA index in the diagnosis of ovarian cancer. 2019-04-01 · Serum levels of CA125 and HE4, and ROMA index were higher in patients with different types of malignant tumor than those in corresponding benign group. Serum HE4, serum CA125, and ROMA index had better performance in the diagnosis of postmenopausal ovarian cancer than that of premenopausal ovarian cancer. HE4 and ROMA index which reference intervals are established according to the menopausal status have important clinical significance in the diagnosis of ovarian cancer.
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Denna oberoende valideringsstudie visade liknande prestationsindex som de nyligen publicerade. Men i denna studie ökade HE4 och ROMA inte upptäckten Förutom cancer kan en liten tumörmarkör ca 125, en förhöjd blodnivå, Analys för tumör markörer Ca.8 HE4-114.9, index roma 38.65 Kan det För att beräkna ROMA-indexet används en matematisk modell som baseras på ovarian tumörmarkörer: Inte 4 och CA125.

HE4 är dock liksom CA125 inte specifik för äggstockscancer och svår att tolka hos kvinnor med Algorithm (ROMA), där en algoritm av. HE4 och CA125 misk status och Charlson komorbiditets index (CCI ). Totalt 109 333 Tumorski biljezi HE4 i ROMA indeks u ranom otkrivanju karcinoma jajnika.
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Although the dual measurement of CA125 and HE4 is apparently the best diagnostic tool over and above ROMA algorithms; the fact of including ages in the ROMA model could be a valuable contribution for diagnosing ovarian cancer [ 68 ].

Results: HE4 had significantly higher concentrations in ovarian cancer than benign gynecologic disorders (p < 0.005). Tumor marker sensitivity in ovarian cancer was 78% for HE4, 63% for CA125, and 88% for ROMA index at 95% specificity. 2019-04-01 This online calculator tool is based on the ROMA slide rule, a tool to help approximate the risk of epithelial ovarian cancer using CA125 and HE4 test values. It is designed to help illustrate how CA125 and HE4 values are combined to estimate risk in both pre- and postmenopausal women.